This framework has been developed as part of the project “Living Evidence to inform health decisions”, a knowledge transfer and capacity building research project involving the design and evaluation of a model strategy to generate, use and apply innovative methods and tools to support health decisions to be based on the most recent evidence. As implementation framework, it seeks to support those who work daily in developing evidence synthesis as part of recommendations in clinical practice guidelines (CPG), health technology assessment reports (HTA) or structured summaries of evidence (SSE) for institutional and public policies in the task of incorporating constantly emerging evidence and generating valid and reliable results that can be used in decision-making.
The framework is divided into four fundamental sections based on the moment in which they must be applied during the evidence synthesis process. Each section poses a series of questions that guide the developers (e.g. technical team) in defining each step of the process.
Section A. What are the problem and its derived questions?
This section seeks to establish the health problem and define the questions that can be derived from the same problem given the possible variations in the population of interest, or in the intervention and its comparator(s).
Questions of this section should be filled out once the health problem or question has been identified as potentially relevant for a “living evidence” approach. There are different set of questions for interventions and for diagnostic test.
Section B. Does the problem or its derived questions warrant a “living evidence” approach?
This section will allow defining whether the characteristics of the available evidence justify addressing the question(s) with a living evidence approach.
Questions of this section should be filled out after running a first pragmatic search aimed to identify the potential eligible studies for answering the questions of interest.
Section C. How the “living evidence” synthesis will be carried out?
This section includes specific guidance on key methodological considerations for planning the process to keep the evidence living for the question working on.
Questions of this section should be filled out during the planning phase of the evidence synthesis that will answer the question selected in Section A.
Section D. Constant monitoring of new evidence (evidence surveillance)
This section seeks to support the evidence surveillance and monitoring process regardless of how often it is planned to be carried out. A series of questions are presented that will guide the user in applying the appropriate criteria to determine when to incorporate the identified evidence into the existing synthesis (“baseline synthesis”) and into the knowledge transfer product that it supports.
Questions of this section should be filled out during the evidence surveillance and monitoring process. The format allows collecting the information necessary to generate a report of the evidence monitoring results (i.e., to update the PRISMA). This section’s format can be used multiple times (each time the evidence is reviewed).
To access each section the electronic formats please click on the icons below. Once you have answered all the questions of a given section, a PDF document will be generated. You will be able to save this document as part of your records or share it with your colleagues.